From Intracellular Biochemistry to Lifestyle Transformation: A Brief Overview…

Redox Balance and Glutathione Restoration: The Role of GGC

Oxidative stress is a core driver of inflammation, disease progression, and accelerated ageing. It occurs when the body’s antioxidant defences are overwhelmed by reactive oxygen species (ROS), damaging cells and tissues.

At the centre of your antioxidant defence is glutathione (GSH). But under sustained stress - whether metabolic, emotional, or environmental - glutathione becomes depleted.

Instead of relying on poorly absorbed oral glutathione, Simplr Health uses gamma-glutamylcysteine (GGC), the immediate precursor to GSH. GGC bypasses the rate-limiting step in synthesis and has been shown to:

• Significantly raise intracellular glutathione levels
• Reduce oxidative stress
• Enhance redox capacity and restore cellular resilience

In inflammatory cell models, GGC outperformed both NAC and GSH in restoring redox balance, improving membrane integrity, and preserving cell viability.

By breaking the oxidative–inflammatory loop at the source, GGC enables tissue repair, immune recalibration, and metabolic reset.

Mitochondrial Optimisation: NR, NAD+, and ATP

Mitochondria are the engines of every cell - and energy is required for every function, from detoxification to cognition. But ATP production depends on the molecule NAD+, which declines with age, illness, and stress.

Simplr Health uses nicotinamide riboside (NR), a clinically validated NAD+ precursor that has been shown to:

• Increase NAD+ levels
• Enhance ATP production
• Improve mitochondrial efficiency
• Activate autophagy and cellular repair
• Support metabolic performance and resilience

NR is especially powerful when paired with GGC, providing both the fuel (NAD+) and protection (GSH) needed for optimal energy production and redox regulation.

Inflammation Control and Insulin Suppression via VLCKD

One of the most inflammatory hormones in the modern body is insulin – especially when chronically elevated due to high-carb diets, snacking, and metabolic dysfunction.

The very low-calorie ketogenic diet (VLCKD) is a clinically supported intervention to lower insulin, enhance metabolic flexibility, and trigger fat adaptation. Research shows VLCKD can:

• Reduce fasting glucose, insulin, HbA1c, triglycerides, CRP, and IL-6
• Support weight loss and reversal of type 2 diabetes
• Improve hormonal and reproductive outcomes in PCOS
• Reduce cardiovascular and inflammatory risk factors

VLCKD also stimulates ketone production, activating repair pathways such as AMPK and sirtuins, which help modulate the brain, gut, and immune system.

Gut Microbiome Modulation: The Gateway to Systemic Resilience

The gut microbiome plays a critical role in modulating immune health, brain function, and systemic inflammation. Simplr Health takes a proactive and intentional approach to microbial optimisation, incorporating:

• Synbiotic supplementation to restore microbial diversity and integrity
• Microbiome testing where clinically indicated to guide more tailored interventions
• Gut–brain–immune axis restoration, supporting neurological, immunological, and metabolic resilience

By rebalancing the microbiome, we improve CNS regulation, inflammatory tone, and energy systems from the inside out - particularly relevant in cases of brain fog, autoimmunity, anxiety, and digestive dysfunction.

Nutrition and Supplementation: Precision Meets Practicality

Simplr Health combines foundational nutrition with cutting-edge nutraceuticals to support every stage of transformation. We ensure:

• Macronutrient adequacy: Prioritising lean protein, fibrous plants, and low-glycaemic loads
• Micronutrient repletion: Based on testing, symptoms, and metabolic need
• Supplemental optimisation: Including GGC, NR, omega-3s, magnesium, mitochondrial cofactors, and synbiotics
• Sustainability and satiety: Real-world, easy-to-follow systems that reduce hunger and promote adherence

This isn’t a diet - it’s a coordinated biochemical upgrade.

Behavioural Change and Performance Coaching

True transformation happens when biology and behaviour align.

Simplr Health integrates performance coaching to help clients:

• Redefine their relationship with food, movement, and health
• Build identity-based habits that last
• Create supportive environments for automatic success
• Shift how they and their situation occur to them, leading to new action and sustained outcomes

Our method is not about willpower - it’s about reprogramming the system that drives your choices.

Advanced Clinical Protocols: Precision Medicine Beyond the Basics

Once foundational systems are stabilised and progress is evident, Simplr Health clients may be offered access to advanced, combinatorial protocols, curated by our expert ecosystem and clinical advisory network.

These include:

• Neuro modulation strategies to rebalance autonomic function and stress responses
• Movement rehabilitation programs to restore structural integration and neuromuscular performance
• Microbiome repair and immune recalibration for clients with persistent or complex inflammatory conditions
• Interventional regenerative and cellular medicine, including:
  • Immune cell therapies for solid tumour management
  • Stem cell-based and exosome therapies for tissue repair and immune modulation
  • Intravenous antioxidant, NAD+, and micronutrient protocols
  • Precision diagnostics and therapeutics for age-related degeneration. 

These offerings are only introduced once the foundational Simplr Health Method has been successfully integrated—ensuring readiness and maximising therapeutic outcomes.

The Full Cycle: From Molecule to Momentum

Here’s how the Simplr Health Method delivers layered, systemic impact:

1. Suppress insulin and inflammation through VLCKD
2. Replenish antioxidant defences with GGC
3. Restore energy metabolism with NR and NAD+ support
4. Modulate brain, gut, and immune pathways via ketone adaptation and synbiotics
5. Support the microbiome with testing-informed precision interventions
6. Ensure nutritional completeness with targeted foods and supplements
7. Embed behavioural transformation with expert performance coaching
8. Access advanced therapies including regenerative, neurological, and cellular interventions

Final Word: From Cell to Self

The Simplr Health Method is more than a protocol - it’s a new paradigm for health.

We don’t offer hacks.

We don’t chase symptoms.

We help you restore and reprogram your biology — and with it, your capacity to live a full, high-performance life.

Request a free 15 minute No-Obligation consultation to discuss your needs and how we might be able to help.